| 1825 King of Releaf | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-sterling-properties-chamberlain | Active |
| 1889 Farms | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-1889-farms-rapid-city | Active |
| 605 Cannabis, LLC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-605-cannabis-llc-worthing | Active |
| AAMS | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-aardvark-alternative-medical-solutions-in | Active |
| Bad River Cannabis | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-bad-river-cannabis-llc-fort-pierre | Active |
| Black Hills Cannabis Care | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-bhcc-llc-rapid-city | Active |
| Butte Valley Farms LLC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-butte-valley-farms-llc-newell | Active |
| Canna-Care | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-pjs-holdings-llc-sioux-falls | Active |
| Cannabis Connection | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-cannabis-connection-huron | Active |
| Cannanaut | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-crichton-barber-degriselles-llc-brandon | Active |
| CC Health | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-cc-health-llc-rapid-city | Active |
| Dakota Dispensaries | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-dakota-dispensaries-llc-watertown | Active |
| Dakota Green Dispensary | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-bhcc-llc-box-elder | Active |
| Dakota Health and Wellness | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-dakota-health-and-wellness-llc-north-siou | Active |
| Dakota Health and Wellness | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-dakota-health-and-wellness-north-sioux-ci | Active |
| Dakota Herb LLC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-dakota-herb-llc-vermillion | Active |
| Dakota Herb LLC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-dakota-herb-llc-sioux-falls | Active |
| Dakota Herb LLC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-dakota-herb-llc-aberdeen | Active |
| Dakota Herb LLC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-dakota-herb-llc-huron | Active |
| Dakota Herbs LLC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-dakota-herbs-llc-brandon | Active |
| Dakota Kind | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-dakota-kind-hot-springs | Active |
| Dakota Natural Growers | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-dakota-natural-growers-inc-vermillion | Active |
| Dakota Natural Solutions Grow | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-dakota-natural-solutions-grow-wessington | Active |
| Dankton Farms | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-dankton-farms-yankton | Active |
| Dispensary of Watertown | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-rbcx-llc-watertown | Active |
| Doing Business As | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-name-location | Active |
| East River Farms LLC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-east-river-farms-llc-sioux-falls | Active |
| Elevate Cannabis Dispensary | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-green-machine-inc-yankton | Active |
| Five Leaf Clover 4.20 | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-five-leaf-clover-4-20-llc-colome | Active |
| Freedom Farms, LLC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-freedom-farms-llc-mission-hill | Active |
| Garden Valley Agriculture | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-garden-valley-agriculture-corsica | Active |
| Genesis Farms | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-genesis-farms-huron | Active |
| Genesis Farms | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-genesis-farms-brookings | Active |
| Genesis Farms | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-genesis-farms-mitchell | Active |
| Genesis Farms | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-genesis-farms-llc-rapid-city | Active |
| Genesis Farms | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-genesis-farms-spearfish | Active |
| Genesis Farms | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-genesis-farms-pierre | Active |
| Genesis Farms, LLC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-genesis-farms-llc-box-elder | Active |
| Genesis Farms, LLC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-genesis-farms-llc-sioux-falls | Active |
| Genesis Farms, LLC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-genesis-farms-llc-yankton | Active |
| Genesis Farms, LLC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-genesis-farms-llc-aberdeen | Active |
| Grass Roots Gardens LLC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-grass-roots-gardens-llc-hartford | Active |
| Groovy Treez | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-cc-smoke-llc-yankton | Active |
| Happy Flower Healing | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-happy-flower-healing-yankton | Active |
| High Plains Cannabis, LLC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-high-plains-cannabis-llc-belle-fourche | Active |
| Indigenous Budz | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-ante-wade-llc-lake-andes | Active |
| Kind Care of South Dakota | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-potsons-llc-north-sioux-city | Active |
| King of ReLeaf | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-stainless-steel-llc-chamberlain | Active |
| Mac's From the Hills | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-mac-s-fth-llc-big-stone-city | Active |
| Meridian Exotics | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-cna-llc-yankton | Active |
| Northern Hills Alternative Health | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-northern-hills-alternative-health-sturgis | Active |
| Pitbull Acres LLC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-pitbull-acres-llc-sturgis | Active |
| Pitbull Acres LLC. | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-pitbull-acres-llc-canistota | Active |
| Puffy's LLC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-puffy-s-llc-sturgis | Active |
| Puffy's LLC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-puffy-s-llc-rapid-city | Active |
| Pure Bliss Dispensary | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-pure-bliss-cannabis-tea | Active |
| Pure Bliss Farms LLC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-pure-bliss-farms-llc-tea | Active |
| Redwater Cannabis Care LLC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-redwater-cannabis-care-llc-belle-fourche | Active |
| Royzzz | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-royzzz-of-sioux-falls-llc-sioux-falls | Active |
| Royzzz of Gavins Point, LLC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-royzzz-of-gavins-point-llc-yankton | Active |
| Royzzz of North Sioux City, LLC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-royzzz-of-north-sioux-city-llc-north-siou | Active |
| Royzzz of Watertown LLC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-royzzz-of-watertown-llc-watertown | Active |
| Rushmore Cannabis Care LLC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-rushmore-cannabis-care-llc-belle-fourche | Active |
| Ruthie's, LLC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-ruthie-s-llc-wagner | Active |
| SDCC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-south-dakota-cannabis-company-colman | Active |
| Superior Buds | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-raftis-enterprise-mitchell-llc-mitchell | Active |
| Terp City | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-rbcxg-llc-watertown | Active |
| The Broken Boot Dispensary | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-the-broken-boot-dispensary-custer | Active |
| The Dispensary | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-the-dispensary-harrisburg | Active |
| The Flower Shop | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-the-flower-shop-aberdeen | Active |
| The Flower Shop | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-the-flower-shop-llc-brookings | Active |
| The Flower Shop LLC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-the-flower-shop-llc-sioux-falls | Active |
| The Flower Shop LLC | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-the-flower-shop-llc-mitchell | Active |
| The Frost Factory | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-the-frost-factory-martin | Active |
| Trails Head Cannabis Company | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-deadwood-growhouse-llc-deadwood | Active |
| True North Dispensary | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-blau-ernte-llc-north-sioux-city | Active |
| Twisted Greens | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-twisted-greens-north-sioux-city | Active |
| Unity Road | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-unity-road-llc-hartford | Active |
| Yellowstone Cannabis Care | Medical Cannabis Cultivation | SD-medical-cannabis-cultivation-bhcc-llc-fort-pierre | Active |