| 605 Cannabis, LLC | Medical Cannabis Manufacturing | SD-medical-cannabis-manufacturing-605-cannabis-llc-worthing | Active |
| Crushmore Cannabis | Medical Cannabis Manufacturing | SD-medical-cannabis-manufacturing-kttk-llc-rapid-city | Active |
| Dakota Health and Wellness | Medical Cannabis Manufacturing | SD-medical-cannabis-manufacturing-dakota-health-and-wellness-llc-north-si | Active |
| Dakota Herb LLC | Medical Cannabis Manufacturing | SD-medical-cannabis-manufacturing-dakota-herb-llc-sioux-falls | Active |
| Dakota Natural Growers | Medical Cannabis Manufacturing | SD-medical-cannabis-manufacturing-dakota-natural-growers-vermillion | Active |
| Dakota Natural Solutions Industries LLC | Medical Cannabis Manufacturing | SD-medical-cannabis-manufacturing-dakota-natural-solutions-industries-llc | Active |
| Genesis Farms, LLC | Medical Cannabis Manufacturing | SD-medical-cannabis-manufacturing-genesis-farms-llc-box-elder | Active |
| Groovy Treez | Medical Cannabis Manufacturing | SD-medical-cannabis-manufacturing-cc-smoke-llc-yankton | Active |
| Happy Flower Healing | Medical Cannabis Manufacturing | SD-medical-cannabis-manufacturing-happy-flower-healing-yankton | Active |
| High Hills LLC | Medical Cannabis Manufacturing | SD-medical-cannabis-manufacturing-high-hills-llc-rapid-city | Active |
| Potanicalz, LLC | Medical Cannabis Manufacturing | SD-medical-cannabis-manufacturing-potanicalz-llc-yankton | Active |
| Prairie Farms | Medical Cannabis Manufacturing | SD-medical-cannabis-manufacturing-prairie-farms-llc-arlington | Active |
| Sodak Selects | Medical Cannabis Manufacturing | SD-medical-cannabis-manufacturing-sodak-selects-tea | Active |
| South Dakota Cannabis Company | Medical Cannabis Manufacturing | SD-medical-cannabis-manufacturing-south-dakota-cannabis-company-coleman | Active |