| Bad River Cannabis | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-bad-river-cannabis-llc-fort-pierre | Active |
| Canna-Care | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-pjs-holdings-llc-sioux-falls | Active |
| Cannabis Connection | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-cannabis-connection-huron | Active |
| CC Health | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-cc-health-llc-rapid-city | Active |
| Dakota Dispensaries | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-dakota-dispensaries-llc-watertown | Active |
| Dakota Green Dispensary | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-bhcc-llc-box-elder | Active |
| Dakota Health and Wellness | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-dakota-health-and-wellness-llc-north-sioux | Active |
| Dakota Herb LLC | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-dakota-herb-llc-vermillion | Active |
| Dakota Herb LLC | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-dakota-herb-llc-huron | Active |
| Dakota Herb LLC | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-dakota-herb-llc-aberdeen | Active |
| Dakota Herbs LLC | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-dakota-herbs-llc-brandon | Active |
| Dakota Kind | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-dakota-kind-hot-springs | Active |
| Dispensary of Watertown | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-rbcx-llc-watertown | Active |
| East River Farms LLC | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-east-river-farms-llc-sioux-falls | Active |
| Elevate Cannabis Dispensary | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-green-machine-inc-yankton | Active |
| Five Leaf Clover 4.20 | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-five-leaf-clover-4-20-llc-colome | Active |
| Genesis Farms | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-genesis-farms-llc-rapid-city | Active |
| Genesis Farms | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-genesis-farms-mitchell | Active |
| Genesis Farms | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-genesis-farms-brookings | Active |
| Genesis Farms | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-genesis-farms-pierre | Active |
| Genesis Farms | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-genesis-farms-huron | Active |
| Genesis Farms | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-genesis-farms-spearfish | Active |
| Genesis Farms | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-genesis-farms-watertown | Active |
| Genesis Farms, LLC | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-genesis-farms-llc-aberdeen | Active |
| Genesis Farms, LLC | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-genesis-farms-llc-yankton | Active |
| Genesis Farms, LLC | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-genesis-farms-llc-sioux-falls | Active |
| Groovy Treez | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-cc-smoke-llc-yankton | Active |
| Happy Flower Healing | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-happy-flower-healing-yankton | Active |
| Indigenous Budz | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-ante-wade-llc-lake-andes | Active |
| Kind Care of South Dakota | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-potsons-llc-north-sioux-city | Active |
| King of ReLeaf | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-stainless-steel-llc-chamberlain | Active |
| Mac's From the Hills | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-mac-s-fth-llc-big-stone-city | Active |
| Northern Hills Alternative Health | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-northern-hills-alternative-health-sturgis | Active |
| Puffy's LLC | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-puffy-s-llc-rapid-city | Active |
| Puffy's LLC | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-puffy-s-llc-sturgis | Active |
| Pure Bliss Dispensary | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-pure-bliss-cannabis-tea | Active |
| Redwater Cannabis Care LLC | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-redwater-cannabis-care-llc-belle-fourche | Active |
| Royzzz | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-royzzz-of-sioux-falls-llc-sioux-falls | Active |
| Royzzz of Gavins Point, LLC | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-royzzz-of-gavins-point-llc-yankton | Active |
| Royzzz of North Sioux City, LLC | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-royzzz-of-north-sioux-city-llc-north-sioux | Active |
| Royzzz of Watertown LLC | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-royzzz-of-watertown-llc-watertown | Active |
| Ruthie's, LLC | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-ruthie-s-llc-wagner | Active |
| Superior Buds | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-raftis-enterprise-mitchell-llc-mitchell | Active |
| Terp City | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-rbcx-llc-aberdeen | Active |
| The Broken Boot Dispensary | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-the-broken-boot-dispensary-custer | Active |
| The Dispensary | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-the-dispensary-harrisburg | Active |
| The Flower Shop | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-the-flower-shop-aberdeen | Active |
| The Flower Shop | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-the-flower-shop-llc-brookings | Active |
| The Flower Shop LLC | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-the-flower-shop-llc-mitchell | Active |
| The Flower Shop LLC | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-the-flower-shop-llc-sioux-falls | Active |
| Trails Head Cannabis Company | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-deadwood-growhouse-llc-deadwood | Active |
| True North Dispensary | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-blau-ernte-llc-north-sioux-city | Active |
| Unity Road | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-unity-road-llc-hartford | Active |
| Yellowstone Cannabis Care | Medical Cannabis Dispensary | SD-medical-cannabis-dispensary-bhcc-llc-fort-pierre | Active |